This work got rich rewards from Synbiopunk Challenge sponsored by Ailurus Biotechnology, Miracleplus, Biosysen.
It’s our great honor to develop program based on AlphaFold v2.0 from DeepMind. A part of our computation was done on Colab Pro and Colab Pro+ , we thankGoogle for providing inexpensive computational devices and open source.
With our most gratitude, Dr. Longxing Cao from Westlake University provided computational protein design technical support. We thank Kaize Shen from China Pharmaceutical University for advices about molecule docking.
Last, The International Directed Evolution Competition inspired us to explore this field. We thank iDEC for providing such an opportunity.